Iphepha lakamuva elishicilelwe ku-Journal of Physiology lajulisa icala lemiphumela ekhuthaza ubusha yokuzivocavoca ezintweni ezigugayo, yakhela emsebenzini wangaphambilini owenziwa ngamagundane elebhu esondela ekupheleni kwesikhathi sawo sokuphila semvelo ayekwazi ukufinyelela isondo lokuzivocavoca elinesisindo.
Iphepha elinemininingwane eminingi, "Isiginesha yamangqamuzana echaza ukuzijwayeza ukuvivinya umzimba nokuguga kanye ne-vivo partial reprogramming in skeletal muscle," ibala ababhali ababambisene nabo abayi-16, abayisithupha kubo abangamalungu e-U of A. Umbhali ohambisanayo nguKevin Murach, uprofesa osizayo ku-U of A's Department of Health, Human Performance and Recreation, futhi umbhali wokuqala nguRonald G. Jones III, Ph.D.umfundi eMurach's Molecular Muscle Mass Regulation Laboratory.
Kuleli phepha, abacwaningi baqhathanisa amagundane asebekhulile ayekwazi ukufinyelela isondo lokuzivocavoca elinesisindo namagundane ayenziwe kabusha i-epigenetic ngokusebenzisa ukubonakaliswa kwezinto ze-Yamanaka.
Izici ze-Yamanaka ziyizici ezine zokulotshwa kwamaprotheni (ezikhonjwe njengo-Oct3/4, i-Sox2, i-Klf4 kanye ne-c-Myc, evamise ukufushaniswa ibe yi-OKSM) ezingabuyisela amaseli acaciswe kakhulu (njengeseli lesikhumba) abuyele ku-stem cell, okuyi-stem cell. isimo esincane futhi esivumelana nezimo.I-Nobel Prize in Physiology or Medicine yaklonyeliswa uDkt. Shinya Yamanaka ngalokhu kutholakala ngo-2012. Ngemithamo elungile, ukufaka izici ze-Yamanaka emzimbeni wonke kumagundane kungathuthukisa izimpawu zokuguga ngokulingisa ukuzivumelanisa nezimo okuvamile kwabasebasha. amaseli.
Kulezi zici ezine, i-Myc ibangelwa ukuzivocavoca kwemisipha yamathambo.I-Myc ingase isebenze njengesikhuthazo esingokwemvelo esibangelwa ukuhlela kabusha emisipha, okuyenza ibe iphuzu eliwusizo lokuqhathanisa phakathi kwamaseli ahlelwe kabusha ngokuveza izici namaseli e-Yamanaka ahlelwe kabusha ngokuzivocavoca - "ukuhlelwa kabusha" esimweni sakamuva okubonisa ukuthi ukuvuselela kwemvelo kungashintsha ukufinyeleleka nokuvezwa kwezakhi zofuzo.
Abacwaningi baqhathanisa imisipha yamathambo amagundane ayevunyelwe ukuzivocavoca sekwephuzile empilweni nemisipha yamathambo amagundane ayegcizelela kakhulu i-OKSM emisipha yawo, kanye namagundane ashintshwe izakhi ezikhawulelwe ekuchazeni ngokweqile kwe-Myc nje emisipha yabo.
Ekugcineni, ithimba linqume ukuthi ukuzivocavoca kuthuthukisa iphrofayili ye-molecular ehambisana ne-epigenetic partial programming.Okusho ukuthi: ukuvivinya umzimba kungalingisa izici zephrofayili yamangqamuzana emisipha eye yavezwa izici ze-Yamanaka (ngaleyo ndlela ibonisa izici zamangqamuzana zamangqamuzana asemasha).Lo mphumela onenzuzo wokuzivivinya ngokwengxenye ungabalelwa ezenzweni ezithile ze-Myc emsipha.
Nakuba kungaba lula ukucabangela ukuthi ngolunye usuku singakwazi ukusebenzisa i-Myc emisipha ukuze sifinyelele imiphumela yokuzivocavoca, ngaleyo ndlela sigweme umsebenzi onzima wangempela, uMurach uxwayisa ukuthi kungaba isiphetho esingalungile sokuthola.
Okokuqala, i-Myc ngeke ikwazi ukuphindaphinda yonke imiphumela engezansi yokuzivocavoca umzimba wonke.Kuphinde kube yimbangela yezimila kanye nomdlavuza, ngakho-ke kunezingozi zemvelo zokusebenzisa indlela ebonakala ngayo.Esikhundleni salokho, uMurach ucabanga ukuthi ukuxhaphaza i-Myc kungase kusetshenziswe kangcono njengesu lokuhlola ukuqonda ukuthi ukubuyisela kanjani ukuzijwayeza ukujwayela imisipha emidala ekhombisa ukusabela okwehlayo.Kungenzeka futhi ukuthi kuyindlela yokushaja kakhulu impendulo yosomkhathi ku-zero gravity noma abantu abavaleleke ekuphumuleni kombhede abanomthamo olinganiselwe wokujima.I-Myc inemiphumela eminingi, emihle nemibi, ngakho-ke ukuchaza izinzuzo kungaholela ekwelashweni okuphephile okungasebenza kahle kubantu emgwaqeni.
UMurach ubona ucwaningo lwabo njengokuqinisekisa okwengeziwe kokuzivocavoca njenge-polypill."Ukuzivocavoca yisidakamizwa esinamandla kunawo wonke esinawo," esho, futhi kufanele kuthathwe njengokuthuthukisa impilo - futhi okungase kunwebe impilo - ukwelashwa okuhambisana nemithi nokudla okunempilo.
Ababhali abakanye noMurach noJones e-U of A bahlanganisa noprofesa wesayensi yokuvivinya umzimba u-Nicholas Greene, kanye nabacwaningi ababa nesandla uFrancielly Morena Da Silva, uSeongkyun Lim noSabin Khadgi.
Isikhathi sokuthumela: Mar-02-2023